Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways.
Chem Biol Interact
; 281: 106-110, 2018 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-29289488
ABSTRACT
The aim of this study was to investigate the effects of zingerone (ZGR) on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate underlying mechanisms. ZGR is a phenolic alkanone isolated from ginger, and has potential health benefits. Mice were treated intravenously with ZGR at 12â¯h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by ZGR. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that ZGR protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.
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Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
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Fallo Hepático Agudo
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Sustancias Protectoras
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Guayacol
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Idioma:
En
Revista:
Chem Biol Interact
Año:
2018
Tipo del documento:
Article