De-RSKing ERK - regulation of ERK1/2-RSK dissociation by phosphorylation within a disordered motif.
FEBS J
; 285(1): 42-45, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-29314599
ABSTRACT
The protein kinases ERK1/2 and RSK associate in unstimulated cells but must separate to target other substrates. In this issue, Gógl et al. show that phosphorylation of RSK by active ERK1/2 culminates in the formation of an intramolecular charge clamp between Lys729 and the phosphate group on Ser732. This promotes the dissociation of ERK1/2 from RSK allowing them to engage with other targets.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas Activadas por Mitógenos
/
Sistema de Señalización de MAP Quinasas
Idioma:
En
Revista:
FEBS J
Asunto de la revista:
BIOQUIMICA
Año:
2018
Tipo del documento:
Article