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Female gender and mortality risk in decompensated heart failure.
Scrutinio, Domenico; Guida, Pietro; Passantino, Andrea; Lagioia, Rocco; Raimondo, Rosa; Venezia, Mario; Ammirati, Enrico; Oliva, Fabrizio; Stucchi, Miriam; Frigerio, Maria.
Afiliación
  • Scrutinio D; Istituti Clinici Scientifici Maugeri SPA SB, I.R.C.C.S. Division of Cardiology and Cardiac Rehabilitation, Institute of Cassano Murge, Bari, Italy. Electronic address: domenico.scrutinio@icsmaugeri.it.
  • Guida P; Istituti Clinici Scientifici Maugeri SPA SB, I.R.C.C.S. Division of Cardiology and Cardiac Rehabilitation, Institute of Cassano Murge, Bari, Italy.
  • Passantino A; Istituti Clinici Scientifici Maugeri SPA SB, I.R.C.C.S. Division of Cardiology and Cardiac Rehabilitation, Institute of Cassano Murge, Bari, Italy.
  • Lagioia R; Istituti Clinici Scientifici Maugeri SPA SB, I.R.C.C.S. Division of Cardiology and Cardiac Rehabilitation, Institute of Cassano Murge, Bari, Italy.
  • Raimondo R; Istituti Clinici Scientifici Maugeri SPA SB, I.R.C.C.S. Division of Cardiology and Cardiac Rehabilitation, Institute of Tradate, Varese, Italy.
  • Venezia M; Istituti Clinici Scientifici Maugeri SPA SB, Institute of Ginosa Marina, Taranto, Italy.
  • Ammirati E; "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy.
  • Oliva F; "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy.
  • Stucchi M; "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy.
  • Frigerio M; "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy.
Eur J Intern Med ; 51: 34-40, 2018 05.
Article en En | MEDLINE | ID: mdl-29317139
ABSTRACT

BACKGROUND:

Still there is conflicting evidence about gender-related differences in prognosis among patients with heart failure. This prognostic uncertainty may have implications for risk stratification and planning management strategy. The aim of the present study was to explore the association between gender and one-year mortality in patients admitted with acute decompensated heart failure (ADHF).

METHODS:

We studied 1513 patients. The Cumulative Incidence Function (CIF) method was used to estimate the absolute rate of mortality, heart transplantation (HT)/ventricular assist device (VAD) implantation, and survival free of HT/VAD implantation at 1year. An interaction analysis was performed to assess the association between covariates, gender, and mortality risk. Propensity score matching and Cox regression were used to compare mortality rates in the gender subgroups.

RESULTS:

The CIF estimates of 1-year mortality, HT/VAD implantation, and survival free of HT/VAD implantation at 1year were 33.1%, 7.0%, and 59.9% for women and 30.2%, 10.2%, and 59.6% for men, respectively. Except for diabetes, there was no significant interaction between gender, covariates, and mortality risk. In the matched cohort, the hazard ratio of death for women was 1.19 (95% confidence intervals [CIs] 0.90-1.59; p=.202). After adjusting for age and baseline risk, the hazard ratio of death for women was 1.18 (95% CIs 0.95-1.43; p=.127). The use of gender-specific predictive models did not allow improving the accuracy of risk prediction.

CONCLUSIONS:

Our data strongly suggest that women and men have comparable outcome in the year following a hospitalization for ADHF.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Factores Sexuales / Insuficiencia Cardíaca Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: Europa Idioma: En Revista: Eur J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2018 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Factores Sexuales / Insuficiencia Cardíaca Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: Europa Idioma: En Revista: Eur J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2018 Tipo del documento: Article