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A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
Mercer, Robert C C; Daude, Nathalie; Dorosh, Lyudmyla; Fu, Ze-Lin; Mays, Charles E; Gapeshina, Hristina; Wohlgemuth, Serene L; Acevedo-Morantes, Claudia Y; Yang, Jing; Cashman, Neil R; Coulthart, Michael B; Pearson, Dawn M; Joseph, Jeffrey T; Wille, Holger; Safar, Jiri G; Jansen, Gerard H; Stepanova, Maria; Sykes, Brian D; Westaway, David.
Afiliación
  • Mercer RCC; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Daude N; Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada.
  • Dorosh L; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Fu ZL; National Research Council of Canada, Edmonton, Alberta, Canada.
  • Mays CE; Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, Canada.
  • Gapeshina H; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Wohlgemuth SL; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
  • Acevedo-Morantes CY; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Yang J; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Cashman NR; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Coulthart MB; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Pearson DM; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Joseph JT; Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
  • Wille H; Canadian Creutzfeldt-Jakob Disease Surveillance System, Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Ottawa, Ontario, Canada.
  • Safar JG; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
  • Jansen GH; Hotchkiss Brain Institute and Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada.
  • Stepanova M; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
  • Sykes BD; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
  • Westaway D; Departments of Pathology and Neurology, School of Medicine Case Western Reserve University, Cleveland, Ohio, United States of America.
PLoS Pathog ; 14(1): e1006826, 2018 01.
Article en En | MEDLINE | ID: mdl-29338055
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Gerstmann-Straussler-Scheinker / Enfermedades por Prión / Proteínas PrPSc / Mutación Idioma: En Revista: PLoS Pathog Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Gerstmann-Straussler-Scheinker / Enfermedades por Prión / Proteínas PrPSc / Mutación Idioma: En Revista: PLoS Pathog Año: 2018 Tipo del documento: Article