A new coumarin from stem bark of Calophyllum wallichianum.
Nat Prod Res
; 32(21): 2565-2570, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-29355031
ABSTRACT
A phytochemical study carried out on the plant, Calophyllum wallichianum has led to the isolation of a new coumarin, wallimarin T (1) and a known coumarin, calanolide E (2) along with two common triterpenes, friedelin (3) and stigmasterol (4). The structures of these compounds were elucidated with the aid of spectroscopic analyses such as FT-IR, GC-MS, and NMR. MIC assay against the Bacillus bacteria were conducted on the extracts and this gave MIC values ranging from 0.313 to 1.25 mg/mL. Compound 2 was weakly inhibitory towards the Bacilli strains with MIC values ranging from 0.25-0.50 mg/mL. Wallimarin T (1) was not active towards all four bacteria. Overall, the extracts exhibited weak bactericidal properties whereas compound 2 was not bactericidal on the tested bacteria. The hexane and chloroform extracts of the plant were found to be inhibitors to the growth of Bacillus megaterium, Bacillus cereus, Bacillus pumilus and Bacillus subtilis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cumarinas
/
Calophyllum
/
Corteza de la Planta
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Año:
2018
Tipo del documento:
Article