Associations of Dietary Protein and Fiber Intake with Brain and Blood Amyloid-ß.
J Alzheimers Dis
; 61(4): 1589-1598, 2018.
Article
en En
| MEDLINE
| ID: mdl-29376865
ABSTRACT
Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer's disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-ß (Aß). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain Aß burden (nâ=â541, and nâ=â162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of 'high' brain Aß burden (PiB PET SUVR≥1.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile (pâ=â0.008; pâ=â0.013). Thus, in this cohort, the more protein consumed, the less likelihood of 'high' Aß burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain Aß burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Fibras de la Dieta
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Proteínas en la Dieta
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Péptidos beta-Amiloides
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Enfermedad de Alzheimer
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
País/Región como asunto:
Oceania
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2018
Tipo del documento:
Article