[ALKALOIDS OF UNDERGROUND PARTS OF GEORGIAN FLORA'S ACONITUM ORIENTALE MILL. AND ACONITUM NASUTUM FISCH. EX REICHEMB AND THEIR BIOLOGICAL ACTIVITY].
Georgian Med News
; (274): 164-167, 2018 Jan.
Article
en Ru
| MEDLINE
| ID: mdl-29461247
ABSTRACT
The aim of research was to study underground parts of Aconitum orientale Mill and Aconitum nasutum Fisch exReichemb for the composition of biological active diterpenic alkaloids. The research object was underground parts of Aconitum species. Alkaloids sum was received from raw-material which was alkalined beforehand with chloroform extraction. From the results of research we established, that both species of Georgian flora's Aconitum contains alkaloids lappaconitine, aconitine, karakoline. Underground parts of Aconitum orientale and Aconitum nasutum differ from eath other with composition of alkaloids spectrum. Underground parts of Aconitum orientale contains bases ranaconitine, gigactonine, licoctonine, but underground parts of Aconitum nasutum contains talitizamine, kamakonine, aconosine. Alkaloids' summary substances, which were received from underground parts of Aconitum species spread in Georgia, showed selective cytotoxic activity towards A-549 (lung carcinoma), DLD-1 (intestine adenocarcinoma), WS-1 (human normal fibroblasts).
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Base de datos:
MEDLINE
Asunto principal:
Raíces de Plantas
/
Aconitum
/
Alcaloides
/
Antineoplásicos Fitogénicos
Idioma:
Ru
Revista:
Georgian Med News
Asunto de la revista:
MEDICINA
Año:
2018
Tipo del documento:
Article