INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS FOR EXUDATIVE RETINAL ARTERIAL MACROANEURYSMS.
Retina
; 39(6): 1133-1141, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-29505440
ABSTRACT
PURPOSE:
There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM).METHODS:
Retrospective multicenter interventional study of anti-vascular endothelial growth factor in symptomatic RAMs. Central macular thickness in µm and best-corrected visual acuity in logMar were correlated with the RAM size and distance to the macula. Statistical analyses were performed using paired comparisons and Pearson correlation.RESULTS:
Thirty-two eyes (32 patients) were treated with a mean of 2.7 injections over a mean follow-up of 16.6 months. Initial best-corrected visual acuity correlated with the RAM size and distance to the macula (P = 0.02). Central macular thickness decreased by 131,180, and 211 µm at 1, 2, and 3 months after the first injection (P < 0.001). Best-corrected visual acuity improved by 0.47 and 0.38 Early Treatment Diabetic Retinopathy Study lines at 2 and 3 months (P = 0.005). Anti-vascular endothelial growth factor response correlated with the RAM size (P = 0.04) and the distance to the macula (P = 0.009).CONCLUSION:
Symptomatic RAMs can be treated successfully with anti-vascular endothelial growth factor injections, leading to a decrease in macular edema.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas Recombinantes de Fusión
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Agudeza Visual
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Receptores de Factores de Crecimiento Endotelial Vascular
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Bevacizumab
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Ranibizumab
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Macroaneurisma Arterial de Retina
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Mácula Lútea
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Retina
Año:
2019
Tipo del documento:
Article