The tumor antagonistic steroidal alkaloid Solanidine prompts the intrinsic suicidal signal mediated DFF-40 nuclear import and nucleosomal disruption.

Malojirao, Vikas H; Vigneshwaran, V; Thirusangu, Prabhu; Mahmood, Riaz; Prabhakar, B T

Malojirao, Vikas H; Vigneshwaran, V; Thirusangu, Prabhu; Mahmood, Riaz; Prabhakar, B T.

Afiliación

Malojirao VH; Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga 577203, Karnataka, India.
Vigneshwaran V; Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga 577203, Karnataka, India; Department of Pharmacology, Centre for Lung and Vascular Biology, University of Illinois at Chicago, Chi
Thirusangu P; Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga 577203, Karnataka, India.
Mahmood R; Postgraduate Department of Studies and Research in Biotechnology & Bioinformatics, Kuvempu University, Shankaraghatta, Shivamogga 577203, Karnataka, India.
Prabhakar BT; Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga 577203, Karnataka, India. Electronic address: prabhakarbt1@kussc.org.

Life Sci ; 199: 139-150, 2018 Apr 15.

Article en En | MEDLINE | ID: mdl-29524520

Asunto(s)

Transporte Activo de Núcleo Celular/efectos de los fármacos; Alcaloides/farmacología; Muerte Celular/efectos de los fármacos; Desoxirribonucleasas/metabolismo; Diosgenina/farmacología; Nucleosomas/metabolismo; Proteínas de Unión a Poli-ADP-Ribosa/metabolismo; Células A549; Transporte Activo de Núcleo Celular/fisiología; Alcaloides/uso terapéutico; Animales; Muerte Celular/fisiología; Diosgenina/uso terapéutico; Relación Dosis-Respuesta a Droga; Células HEK293; Células Hep G2; Humanos; Células MCF-7; Melanoma Experimental/tratamiento farmacológico; Melanoma Experimental/metabolismo; Ratones; Ratones Endogámicos BALB C; Ensayos Antitumor por Modelo de Xenoinjerto/métodos

Palabras clave

Apoptosis; Caspase-3; DFF-40; PI3K/Akt; Solanidine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Nucleosomas / Muerte Celular / Transporte Activo de Núcleo Celular / Desoxirribonucleasas / Diosgenina / Alcaloides / Proteínas de Unión a Poli-ADP-Ribosa Tipo de estudio: Prognostic_studies Idioma: En Revista: Life Sci Año: 2018 Tipo del documento: Article

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