Autoimmune and immunogenetic profile of patients with optic neuritis in a population-based cohort.
Mult Scler Relat Disord
; 21: 97-102, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29544193
ABSTRACT
BACKGROUND:
Optic neuritis (ON) is an inflammatory optic neuropathy, where the genetic and autoimmune dependency remains poorly characterized.OBJECTIVE:
To investigate autoimmune and immunogenetic aspects of ON.METHOD:
In a prospective population-based cohort 51 patients with ON were included. At follow up 20 patients had progressed to multiple sclerosis (MS-ON). All patients were screened for neuronal and systemic autoantibodies. HLA genotypes and allele and genotype frequencies of the PTPN22 C1858T and the PD-1.3 single-nucleotide polymorphisms (SNPs) were determined and compared to a cohort of Danish blood donors, acting as healthy controls.RESULTS:
Median follow-up was 366 days (301-430) for MS-ON patients and 375 (range 50-436) for isolated ON (ION). Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG), were positive in two patients, no patients had anti-aquaporin-4 antibodies. Coexisting neural autoantibodies were detected in two patients and in 12 patients other systemic autoantibodies were found. Four (8%) had other autoimmune disorders. A family history of autoimmunity was observed in 12 (24%) and of demyelinating disease in six patients (12%). In MS-ON patients the frequencies of HLA-DQB1*0602 and HLA-DRB1*1501 tended to be higher compared to controls (pâ¯=â¯0.08). Stratification of patients with presence of oligoclonal bands (OCB) showed an association to the HLA-DQB1*0602-HLA-DRB1*1501 haplotype in ION (HLA-DQB1*0602 and HLA-DRB1*1501 (pâ¯=â¯0.03)), and in MS-ON patients (HLA-DQB1*0602 and HLA-DRB1*1501 (pâ¯=â¯0.03)). No significant associations to PTPN22 1858C/T or PD-1.3â¯G/A were found in any group comparison.CONCLUSIONS:
ON patients had a general susceptibility to autoimmunity and two were MOG-IgG positive. HLA-DQB1*0602 and HLA-DRB1*1501 were associated with the presence of OCB in ON patients.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Neuritis Óptica
/
Esclerosis Múltiple
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Mult Scler Relat Disord
Año:
2018
Tipo del documento:
Article