Mechanistic study for the simultaneous determination of metformin and teneligliptin in human plasma using hydrophilic interaction liquid chromatography-MS/MS.

Shah, Priyanka A; Shrivastav, Pranav S; Vanol, Pravin G; Sanyal, Mallika

Shah, Priyanka A; Shrivastav, Pranav S; Vanol, Pravin G; Sanyal, Mallika.

Afiliación

Shah PA; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, Gujarat, India.
Shrivastav PS; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, Gujarat, India.
Vanol PG; Chemistry Department, St Xavier's College, Ahmedabad 380009, Gujarat, India.
Sanyal M; Chemistry Department, St Xavier's College, Ahmedabad 380009, Gujarat, India.

Bioanalysis ; 10(7): 475-488, 2018 Apr 01.

Article en En | MEDLINE | ID: mdl-29561645

Asunto(s)

Cromatografía Liquida/métodos; Inhibidores de la Dipeptidil-Peptidasa IV/uso terapéutico; Hipoglucemiantes/uso terapéutico; Metformina/uso terapéutico; Plasma/metabolismo; Pirazoles/uso terapéutico; Espectrometría de Masas en Tándem/métodos; Tiazolidinas/uso terapéutico; Inhibidores de la Dipeptidil-Peptidasa IV/farmacología; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Hipoglucemiantes/farmacología; Metformina/farmacología; Pirazoles/farmacología; Tiazolidinas/farmacología

Palabras clave

diabetes; electrostatic interaction; enthalpy; exothermic; hydrophilic interaction; hydrophilic interaction liquid chromatography; metformin; retention mechanism; teneligliptin; van't Hoff equation

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Plasma / Pirazoles / Cromatografía Liquida / Tiazolidinas / Espectrometría de Masas en Tándem / Inhibidores de la Dipeptidil-Peptidasa IV / Hipoglucemiantes / Metformina Idioma: En Revista: Bioanalysis Año: 2018 Tipo del documento: Article

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