Structure-kinetic relationship studies of cannabinoid CB<sub>2</sub> receptor agonists reveal substituent-specific lipophilic effects on residence time.

Soethoudt, Marjolein; Hoorens, Mark W H; Doelman, Ward; Martella, Andrea; van der Stelt, Mario; Heitman, Laura H

Structure-kinetic relationship studies of cannabinoid CB₂ receptor agonists reveal substituent-specific lipophilic effects on residence time.

Soethoudt, Marjolein; Hoorens, Mark W H; Doelman, Ward; Martella, Andrea; van der Stelt, Mario; Heitman, Laura H.

Afiliación

Soethoudt M; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
Hoorens MWH; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
Doelman W; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
Martella A; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
Heitman LH; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands. Electronic address: l.h.heitman@lacdr.leidenuniv.nl.

Biochem Pharmacol ; 152: 129-142, 2018 06.

Article en En | MEDLINE | ID: mdl-29574067

Asunto(s)

Agonistas de Receptores de Cannabinoides/síntesis química; Agonistas de Receptores de Cannabinoides/farmacología; Imidazolidinas/química; Imidazolidinas/farmacología; Morfolinas/química; Morfolinas/farmacología; Receptor Cannabinoide CB2/fisiología; Animales; Agonistas de Receptores de Cannabinoides/química; Línea Celular; Cricetinae; Humanos; Cinética; Ligandos; Estructura Molecular; Unión Proteica; Relación Estructura-Actividad

Palabras clave

Cannabinoid CB(2) receptor; Functional potency; Physicochemical properties; Target residence time

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Morfolinas / Receptor Cannabinoide CB2 / Imidazolidinas / Agonistas de Receptores de Cannabinoides Tipo de estudio: Prognostic_studies Idioma: En Revista: Biochem Pharmacol Año: 2018 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google