Your browser doesn't support javascript.
loading
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills, Evanna L; Ryan, Dylan G; Prag, Hiran A; Dikovskaya, Dina; Menon, Deepthi; Zaslona, Zbigniew; Jedrychowski, Mark P; Costa, Ana S H; Higgins, Maureen; Hams, Emily; Szpyt, John; Runtsch, Marah C; King, Martin S; McGouran, Joanna F; Fischer, Roman; Kessler, Benedikt M; McGettrick, Anne F; Hughes, Mark M; Carroll, Richard G; Booty, Lee M; Knatko, Elena V; Meakin, Paul J; Ashford, Michael L J; Modis, Louise K; Brunori, Gino; Sévin, Daniel C; Fallon, Padraic G; Caldwell, Stuart T; Kunji, Edmund R S; Chouchani, Edward T; Frezza, Christian; Dinkova-Kostova, Albena T; Hartley, Richard C; Murphy, Michael P; O'Neill, Luke A.
Afiliación
  • Mills EL; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Ryan DG; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Prag HA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Dikovskaya D; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK.
  • Menon D; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Zaslona Z; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
  • Jedrychowski MP; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.
  • Costa ASH; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Higgins M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Hams E; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Szpyt J; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Runtsch MC; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.
  • King MS; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.
  • McGouran JF; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Fischer R; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Kessler BM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • McGettrick AF; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
  • Hughes MM; School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Carroll RG; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK.
  • Booty LM; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK.
  • Knatko EV; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Meakin PJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Ashford MLJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Modis LK; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK.
  • Brunori G; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK.
  • Sévin DC; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
  • Fallon PG; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.
  • Caldwell ST; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.
  • Kunji ERS; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.
  • Chouchani ET; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK.
  • Frezza C; GlaxoSmithKline, Park Road, Ware, Hertfordshire, UK.
  • Dinkova-Kostova AT; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
  • Hartley RC; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Murphy MP; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
  • O'Neill LA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
Nature ; 556(7699): 113-117, 2018 04 05.
Article en En | MEDLINE | ID: mdl-29590092
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Succinatos / Factor 2 Relacionado con NF-E2 / Proteína 1 Asociada A ECH Tipo Kelch / Antiinflamatorios Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Succinatos / Factor 2 Relacionado con NF-E2 / Proteína 1 Asociada A ECH Tipo Kelch / Antiinflamatorios Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article