Your browser doesn't support javascript.
loading
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
Chen, Huifen; Volgraf, Matthew; Do, Steven; Kolesnikov, Aleksandr; Shore, Daniel G; Verma, Vishal A; Villemure, Elisia; Wang, Lan; Chen, Yong; Hu, Baihua; Lu, Ai-Jun; Wu, Guosheng; Xu, Xiaofeng; Yuen, Po-Wai; Zhang, Yamin; Erickson, Shawn D; Dahl, Martin; Brotherton-Pleiss, Christine; Tay, Suzanne; Ly, Justin Q; Murray, Lesley J; Chen, Jun; Amm, Desiree; Lange, Wienke; Hackos, David H; Reese, Rebecca M; Shields, Shannon D; Lyssikatos, Joseph P; Safina, Brian S; Estrada, Anthony A.
Afiliación
  • Chen Y; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Hu B; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Lu AJ; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Wu G; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Xu X; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Yuen PW; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Zhang Y; Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Erickson SD; Small Molecule Research, Pharmaceutical Research and Early Drug Development , Hoffmann-La Roche Inc. , 340 Kingsland Street , Nutley , New Jersey 07110 , United States.
  • Dahl M; Small Molecule Research, Pharmaceutical Research and Early Drug Development , Hoffmann-La Roche Inc. , 340 Kingsland Street , Nutley , New Jersey 07110 , United States.
  • Brotherton-Pleiss C; Small Molecule Research, Pharmaceutical Research and Early Drug Development , Hoffmann-La Roche Inc. , 340 Kingsland Street , Nutley , New Jersey 07110 , United States.
  • Amm D; Ion Channels Group, Evotec AG , Manfred Eigen Campus, Essener Bogen 7 , 22419 Hamburg , Germany.
  • Lange W; Ion Channels Group, Evotec AG , Manfred Eigen Campus, Essener Bogen 7 , 22419 Hamburg , Germany.
J Med Chem ; 61(8): 3641-3659, 2018 04 26.
Article en En | MEDLINE | ID: mdl-29590749
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonamidas / Prolina / Profármacos / Canal Catiónico TRPA1 Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonamidas / Prolina / Profármacos / Canal Catiónico TRPA1 Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article