A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry.

Buranda, Tione; Gineste, Catherine; Wu, Yang; Bondu, Virginie; Perez, Dominique; Lake, Kaylin R; Edwards, Bruce S; Sklar, Larry A

Buranda, Tione; Gineste, Catherine; Wu, Yang; Bondu, Virginie; Perez, Dominique; Lake, Kaylin R; Edwards, Bruce S; Sklar, Larry A.

Afiliación

Buranda T; 1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Gineste C; 2 Center for Infectious Diseases and Immunity, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Wu Y; 3 University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Bondu V; 1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Perez D; 1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Lake KR; 1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Edwards BS; 4 Department of Cancer Center, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Sklar LA; 5 Department of Biochemistry, University of New Mexico, Albuquerque, NM, USA.

SLAS Discov ; 23(7): 634-645, 2018 08.

Article en En | MEDLINE | ID: mdl-29608398

Asunto(s)

Antivirales/farmacología; Citometría de Flujo; Ensayos Analíticos de Alto Rendimiento; Orthohantavirus/efectos de los fármacos; Internalización del Virus/efectos de los fármacos; Animales; Biomarcadores; Supervivencia Celular/efectos de los fármacos; Chlorocebus aethiops; Relación Dosis-Respuesta a Droga; Citometría de Flujo/métodos; Orthohantavirus/fisiología; Infecciones por Hantavirus/tratamiento farmacológico; Infecciones por Hantavirus/virología; Humanos; Modelos Biológicos; Reproducibilidad de los Resultados; Células Vero

Palabras clave

G protein; PAC-1; PSI domain; Rap1; cyclic AMP; drug discovery; flow cytometry; hantavirus; high-throughput screen; integrin activation; mechanotransduction

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Orthohantavirus / Internalización del Virus / Ensayos Analíticos de Alto Rendimiento / Citometría de Flujo Tipo de estudio: Prognostic_studies Idioma: En Revista: SLAS Discov Año: 2018 Tipo del documento: Article

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