Pharmacokinetics of Daptomycin in Critically Ill Pediatric Patients.
Antimicrob Agents Chemother
; 62(6)2018 06.
Article
en En
| MEDLINE
| ID: mdl-29610198
ABSTRACT
The pharmacokinetics of daptomycin (10 mg/kg once daily) was studied in 4 critically ill pediatric patients aged 8 to 14 yrs. The area under the concentration-time curve from time zero to infinity (AUC0-∞) of plasma concentrations on day 1 ranged between 123.8 to 663.9 µg · h/ml, with lower values observed in septic and burn patients; clearance ranged from 15.1 to 80.7 ml/h/kg. Higher-than-recommended doses of daptomycin may be needed in septic children to ensure optimal drug exposure. Interpatient variability may suggest a role for therapeutic drug monitoring.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Daptomicina
/
Antibacterianos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2018
Tipo del documento:
Article