The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors.

Pham, Hanh T; Labrie, Lydia; Wijting, Ingeborg E A; Hassounah, Said; Lok, Ka Yee; Portna, Inna; Goring, Mark E; Han, Yingshan; Lungu, Cynthia; van der Ende, Marchina E; Brenner, Bluma G; Boucher, Charles A; Rijnders, Bart J A; van Kampen, Jeroen J A; Mesplède, Thibault; Wainberg, Mark A

Pham, Hanh T; Labrie, Lydia; Wijting, Ingeborg E A; Hassounah, Said; Lok, Ka Yee; Portna, Inna; Goring, Mark E; Han, Yingshan; Lungu, Cynthia; van der Ende, Marchina E; Brenner, Bluma G; Boucher, Charles A; Rijnders, Bart J A; van Kampen, Jeroen J A; Mesplède, Thibault; Wainberg, Mark A.

Afiliación

Pham HT; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Labrie L; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Wijting IEA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Hassounah S; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Lok KY; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands.
Portna I; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Goring ME; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada.
Han Y; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Lungu C; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
van der Ende ME; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Brenner BG; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Boucher CA; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada.
Rijnders BJA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
van Kampen JJA; Department of Viroscience, Erasmus University, Rotterdam, Netherlands.
Mesplède T; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands.
Wainberg MA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

J Infect Dis ; 218(5): 698-706, 2018 07 24.

Article en En | MEDLINE | ID: mdl-29617824

Asunto(s)

Sustitución de Aminoácidos; Farmacorresistencia Viral; Infecciones por VIH/tratamiento farmacológico; Inhibidores de Integrasa VIH/uso terapéutico; VIH/efectos de los fármacos; Compuestos Heterocíclicos con 3 Anillos/uso terapéutico; Carga Viral; VIH/genética; VIH/crecimiento & desarrollo; VIH/aislamiento & purificación; Integrasa de VIH/genética; Integrasa de VIH/metabolismo; Humanos; Quimioterapia de Mantención/métodos; Pruebas de Sensibilidad Microbiana; Mutación Missense; Oxazinas; Piperazinas; Piridonas; Insuficiencia del Tratamiento; Replicación Viral

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH / Inhibidores de Integrasa VIH / Carga Viral / Sustitución de Aminoácidos / Farmacorresistencia Viral / Compuestos Heterocíclicos con 3 Anillos Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Infect Dis Año: 2018 Tipo del documento: Article

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