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Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.
Janssen, Bieneke; Vugts, Danielle J; Wilkinson, Shane M; Ory, Dieter; Chalon, Sylvie; Hoozemans, Jeroen J M; Schuit, Robert C; Beaino, Wissam; Kooijman, Esther J M; van den Hoek, Johan; Chishty, Mansoor; Doméné, Aurélie; Van der Perren, Anke; Villa, Alessandro; Maggi, Adriana; Molenaar, Ger T; Funke, Uta; Shevchenko, Rostislav V; Baekelandt, Veerle; Bormans, Guy; Lammertsma, Adriaan A; Kassiou, Michael; Windhorst, Albert D.
Afiliación
  • Janssen B; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. bieneke.janssen@pennmedicine.upenn.edu.
  • Vugts DJ; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Wilkinson SM; School of Chemistry, University of Sydney, Sydney, Australia.
  • Ory D; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
  • Chalon S; UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
  • Hoozemans JJM; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
  • Schuit RC; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Beaino W; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Kooijman EJM; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • van den Hoek J; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Chishty M; Pharmidex Pharmaceutical Services Ltd., London, United Kingdom.
  • Doméné A; UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
  • Van der Perren A; Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
  • Villa A; Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
  • Maggi A; Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
  • Molenaar GT; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Funke U; BV Cyclotron VU, Amsterdam, The Netherlands.
  • Shevchenko RV; Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Baekelandt V; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
  • Bormans G; BV Cyclotron VU, Amsterdam, The Netherlands.
  • Lammertsma AA; Pharmidex Pharmaceutical Services Ltd., London, United Kingdom.
  • Kassiou M; Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
  • Windhorst AD; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Sci Rep ; 8(1): 6580, 2018 04 26.
Article en En | MEDLINE | ID: mdl-29700413
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Microglía / Radiofármacos / Tomografía de Emisión de Positrones / Imagen Molecular / Receptores Purinérgicos P2X7 / Antagonistas del Receptor Purinérgico P2X Tipo de estudio: Diagnostic_studies Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Microglía / Radiofármacos / Tomografía de Emisión de Positrones / Imagen Molecular / Receptores Purinérgicos P2X7 / Antagonistas del Receptor Purinérgico P2X Tipo de estudio: Diagnostic_studies Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article