Hydrocephalus after Intrathecal Administration of Dextran to Rhesus Macaques (Macaca mulatta).
Comp Med
; 68(3): 227-232, 2018 06 01.
Article
en En
| MEDLINE
| ID: mdl-29776458
ABSTRACT
Dextrans have been used extensively as medical therapies and labeling agents in biomedical research to investigate the blood-brain barrier and CSF flow and absorption. Adverse effects from dextrans include anaphylactic reaction and dilation of the cerebral ventricles due to administration into the subarachnoid space. This retrospective study describes 51 rhesus macaques (Macaca mulatta) that received dextran intrathecally. The purpose of intrathecal administration was to enable detection of long-lived, dextran-labeled macrophages and to study monocyte-macrophage turnover in the CNS of SIV- or SHIV- infected and uninfected animals by using immunofluorescence. Of the 51 dextran-treated macaques, 8 that received dextran diluted in saline developed hydrocephalus; 6 of these 8 animals exhibited neurologic signs. In contrast, none of the macaques that received intrathecal dextran diluted in PBS developed hydrocephalus. These data suggest the use of saline diluent and the duration of dextran exposure as potential factors contributing to hydrocephalus after intrathecal dextran in rhesus macaques.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Inyecciones Espinales
/
Dextranos
/
Solución Salina
/
Hidrocefalia
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Macaca mulatta
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Comp Med
Asunto de la revista:
MEDICINA
/
MEDICINA VETERINARIA
Año:
2018
Tipo del documento:
Article