Circadian hemodynamic characteristics in hypertensive patients with primary aldosteronism.
J Hypertens
; 36(11): 2260-2268, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-29846324
ABSTRACT
OBJECTIVE:
The present study aimed to compare circadian hemodynamic characteristics in hypertensive patients with and without primary aldosteronism.METHODS:
Circadian hemodynamics, including 24-h brachial and central blood pressure (BP), SBP variability indices, central pulse wave velocity (PWV), augmentation index (AIx@75), cardiac index, and total vascular resistance (TVR), were evaluated using an oscillometric device, Mobil-O-Graph, in 60 patients with primary aldosteronism (63.4±13.3 years, 47% women) and 120 age-matched and sex-matched patients with essential hypertension.RESULTS:
Office SBP, PWV, AIx@75, and BP variability indices were similar between groups; however, 24-h brachial (124â±â14 vs 130â±â11âmmHg) as well as central (112â±â12 vs 120â±â10 mmHg) SBP was higher (both Pâ<â0.01), and the difference between 24-h brachial and central SBP (11â±â5 vs 9â±â3âmmHg, Pâ<â0.05), an index of pressure amplification, was smaller in primary aldosteronism than in essential hypertension. In both groups, cardiac index decreased from daytime to night-time (both Pâ<â0.01), but this decrease was smaller in primary aldosteronism (Pâ<â0.05). During daytime, TVR in primary aldosteronism was higher than that in essential hypertension (Pâ<â0.05), and the significant increase of TVR from daytime to night-time was lost in primary aldosteronism. In a multivariate stepwise regression model, primary aldosteronism emerged as an independent predictor of 24-h central SBP as well as the difference between 24-h brachial and central SBP.CONCLUSION:
Our results demonstrated that circadian hemodynamics in primary aldosteronism patients are characterized by increased central SBP, smaller disparity between brachial and central SBP, and disturbed circadian hemodynamic variation.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ritmo Circadiano
/
Hipertensión Esencial
/
Hiperaldosteronismo
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Hypertens
Año:
2018
Tipo del documento:
Article