Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[<sup>18</sup>F]Fluoroethoxy)phenyl)-5-Methylpyrazolo[1,5-a]Pyrimidin-3-yl)-N,N-Diethylacetamide (<sup>18</sup>F-VUIIS1018A) to Image Glioma.

Tang, Dewei; Li, Jun; Nickels, Michael L; Huang, Gang; Cohen, Allison S; Manning, H Charles

Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)-5-Methylpyrazolo[1,5-a]Pyrimidin-3-yl)-N,N-Diethylacetamide (¹⁸F-VUIIS1018A) to Image Glioma.

Tang, Dewei; Li, Jun; Nickels, Michael L; Huang, Gang; Cohen, Allison S; Manning, H Charles.

Afiliación

Tang D; Center for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Li J; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Pudong New District, Shanghai, 200127, China.
Nickels ML; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Huang G; Vanderbilt Center for Molecular Probes (CMP), Vanderbilt University Medical School, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232-2310, USA.
Cohen AS; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Manning HC; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.

Mol Imaging Biol ; 21(1): 113-121, 2019 02.

Article en En | MEDLINE | ID: mdl-29869061

Asunto(s)

Neoplasias Encefálicas/diagnóstico; Radioisótopos de Flúor/farmacocinética; Glioma/diagnóstico; Tomografía de Emisión de Positrones/métodos; Pirazoles/farmacocinética; Pirimidinas/farmacocinética; Animales; Neoplasias Encefálicas/patología; Proteínas Portadoras/agonistas; Proteínas Portadoras/metabolismo; Progresión de la Enfermedad; Evaluación Preclínica de Medicamentos; Glioma/patología; Ligandos; Imagen por Resonancia Magnética; Masculino; Ratas; Ratas Wistar; Receptores de GABA-A/metabolismo; Células Tumorales Cultivadas

Palabras clave

Cancer imaging; DPA-714; Glioma; Molecular imaging; PET; TSPO; VUIIS1018A

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Neoplasias Encefálicas / Radioisótopos de Flúor / Tomografía de Emisión de Positrones / Glioma Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Imaging Biol Asunto de la revista: BIOLOGIA MOLECULAR / DIAGNOSTICO POR IMAGEM Año: 2019 Tipo del documento: Article

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