Microenvironment Imbalance of Spinal Cord Injury.
Cell Transplant
; 27(6): 853-866, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29871522
ABSTRACT
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient physiology and psychology. The microenvironment of the injured spinal cord is complicated. According to our previous work and the advancements in SCI research, 'microenvironment imbalance' is the main cause of the poor regeneration and recovery of SCI. Microenvironment imbalance is defined as an increase in inhibitory factors and decrease in promoting factors for tissues, cells and molecules at different times and spaces. There are imbalance of hemorrhage and ischemia, glial scar formation, demyelination and re-myelination at the tissue's level. The cellular level imbalance involves an imbalance in the differentiation of endogenous stem cells and the transformation phenotypes of microglia and macrophages. The molecular level includes an imbalance of neurotrophic factors and their pro-peptides, cytokines, and chemokines. The imbalanced microenvironment of the spinal cord impairs regeneration and functional recovery. This review will aid in the understanding of the pathological processes involved in and the development of comprehensive treatments for SCI.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Traumatismos de la Médula Espinal
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Cell Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2018
Tipo del documento:
Article