Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease.

Chang, Y-T; Huang, C-W; Huang, S-H; Hsu, S-W; Chang, W-N; Lee, J-J; Chang, C-C

Chang, Y-T; Huang, C-W; Huang, S-H; Hsu, S-W; Chang, W-N; Lee, J-J; Chang, C-C.

Afiliación

Chang YT; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Huang CW; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Huang SH; Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Hsu SW; Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Chang WN; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Lee JJ; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Chang CC; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Genes Brain Behav ; 18(5): e12490, 2019 06.

Article en En | MEDLINE | ID: mdl-29883038

Asunto(s)

Enfermedad de Alzheimer/genética; Apolipoproteínas E/genética; Conectoma; Memoria; Proteínas de Ensamble de Clatrina Monoméricas/genética; Anciano; Enfermedad de Alzheimer/diagnóstico por imagen; Enfermedad de Alzheimer/fisiopatología; Femenino; Humanos; Imagen por Resonancia Magnética; Masculino; Polimorfismo de Nucleótido Simple; Tomografía de Emisión de Positrones

Palabras clave

AD; APOE; FDG-PET; PICALM; default mode network; genetic interactions; hippocampus; memory impairment; metabolic connectivity; posterior cingulate cortex

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Apolipoproteínas E / Proteínas de Ensamble de Clatrina Monoméricas / Enfermedad de Alzheimer / Conectoma / Memoria Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Genes Brain Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / GENETICA Año: 2019 Tipo del documento: Article

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