CDP-glycerol inhibits the synthesis of the functional <i>O</i>-mannosyl glycan of &#945;-dystroglycan.

Imae, Rieko; Manya, Hiroshi; Tsumoto, Hiroki; Osumi, Kenji; Tanaka, Tomohiro; Mizuno, Mamoru; Kanagawa, Motoi; Kobayashi, Kazuhiro; Toda, Tatsushi; Endo, Tamao

CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan.

Imae, Rieko; Manya, Hiroshi; Tsumoto, Hiroki; Osumi, Kenji; Tanaka, Tomohiro; Mizuno, Mamoru; Kanagawa, Motoi; Kobayashi, Kazuhiro; Toda, Tatsushi; Endo, Tamao.

Afiliación

Imae R; Molecular Glycobiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.
Manya H; Molecular Glycobiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan. Electronic address: manya@tmig.or.jp.
Tsumoto H; Proteome Research, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.
Osumi K; Laboratory of Glyco-organic Chemistry, The Noguchi Institute, Tokyo 173-0003, Japan.
Tanaka T; Laboratory of Glyco-organic Chemistry, The Noguchi Institute, Tokyo 173-0003, Japan.
Mizuno M; Laboratory of Glyco-organic Chemistry, The Noguchi Institute, Tokyo 173-0003, Japan.
Kanagawa M; Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
Kobayashi K; Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
Toda T; Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan; Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Endo T; Molecular Glycobiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.

J Biol Chem ; 293(31): 12186-12198, 2018 08 03.

Article en En | MEDLINE | ID: mdl-29884773

Asunto(s)

Distroglicanos/metabolismo; Glicerol/metabolismo; Distrofias Musculares/metabolismo; Polisacáridos/metabolismo; Glicerol/química; Glicosilación; Humanos; Cinética; Proteínas de la Membrana/química; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Distrofias Musculares/genética; Pentosafosfatos/metabolismo; Pentosiltransferasa; Proteínas/química; Proteínas/genética; Proteínas/metabolismo

Palabras clave

CDP-glycerol; dystroglycan; enzyme catalysis; fukutin; glycobiology; glycosylation; glycosyltransferase; muscular dystrophy; protein glycosylation; α-dystroglycanopathy

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Polisacáridos / Distroglicanos / Glicerol / Distrofias Musculares Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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