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Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
Zhang, Peng; Gorman, Jason; Geng, Hui; Liu, Qingbo; Lin, Yin; Tsybovsky, Yaroslav; Go, Eden P; Dey, Barna; Andine, Tsion; Kwon, Alice; Patel, Mit; Gururani, Deepali; Uddin, Ferzan; Guzzo, Christina; Cimbro, Raffaello; Miao, Huiyi; McKee, Krisha; Chuang, Gwo-Yu; Martin, Loïc; Sironi, Francesca; Malnati, Mauro S; Desaire, Heather; Berger, Edward A; Mascola, John R; Dolan, Michael A; Kwong, Peter D; Lusso, Paolo.
Afiliación
  • Zhang P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Geng H; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Liu Q; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Lin Y; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Tsybovsky Y; Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Go EP; Department of Chemistry, University of Kansas, Lawrence, KS 66047, USA.
  • Dey B; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Andine T; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Kwon A; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Patel M; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Gururani D; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Uddin F; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Guzzo C; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Cimbro R; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Miao H; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • McKee K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Chuang GY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Martin L; CEA, Joliot, Service d'Ingénierie Moléculaire des Protéines, 91191 Gif-sur-Yvette, France.
  • Sironi F; Department of Biological and Technological Research, San Raffaele Scientific Institute, Milan 20122, Italy.
  • Malnati MS; Department of Biological and Technological Research, San Raffaele Scientific Institute, Milan 20122, Italy.
  • Desaire H; Department of Chemistry, University of Kansas, Lawrence, KS 66047, USA.
  • Berger EA; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Dolan MA; Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Lusso P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address: plusso@niaid.nih.gov.
Cell Host Microbe ; 23(6): 832-844.e6, 2018 06 13.
Article en En | MEDLINE | ID: mdl-29902444
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Unión Proteica / Antígenos CD4 / VIH-1 / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Estabilidad Proteica / Dominios Proteicos Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Unión Proteica / Antígenos CD4 / VIH-1 / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Estabilidad Proteica / Dominios Proteicos Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2018 Tipo del documento: Article