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Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood.
Albaugh, Matthew D; Ivanova, Masha; Chaarani, Bader; Orr, Catherine; Allgaier, Nicholas; Althoff, Robert R; D' Alberto, Nicholas; Hudson, Kelsey; Mackey, Scott; Spechler, Philip A; Banaschewski, Tobias; Brühl, Rüdiger; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Goodman, Robert; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Kappel, Viola; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Penttilä, Jani; Poustka, Luise; Paus, Tomás; Smolka, Michael N; Struve, Maren; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Garavan, Hugh; Potter, Alexandra S.
Afiliación
  • Albaugh MD; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Ivanova M; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Chaarani B; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Orr C; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Allgaier N; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Althoff RR; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • D' Alberto N; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Hudson K; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Mackey S; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Spechler PA; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
  • Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Brühl R; Physikalisch-Technische Bundesanstalt [PTB], Abbestr. 2-12, Berlin-Charlottenburg, Germany.
  • Bokde ALW; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin 2, Ireland.
  • Bromberg U; University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Büchel C; University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Cattrell A; Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Conrod PJ; Department of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, QC, Canada.
  • Desrivières S; Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Flor H; Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Frouin V; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Gallinat J; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
  • Goodman R; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Gowland P; King's College London Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Grimmer Y; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
  • Heinz A; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Kappel V; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
  • Martinot JL; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
  • Martinot MP; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes-Sorbonne Paris Cité.
  • Nees F; Maison de Solenn, Paris, France.
  • Papadopoulos Orfanos D; INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, France.
  • Penttilä J; University Paris Descartes, Paris, France AP-HP, Department of Adolescent Psychopathology and Medicine, Maison De Solenn, Cochin Hospital, Paris, France.
  • Poustka L; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Paus T; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
  • Smolka MN; University of Tampere, Medical School, Tampere, Finland.
  • Struve M; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Walter H; Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Whelan R; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Schumann G; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Garavan H; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
  • Potter AS; Department of Psychology, University College Dublin, Dublin 4, Ireland.
Cereb Cortex ; 29(5): 1866-1874, 2019 05 01.
Article en En | MEDLINE | ID: mdl-29912404
Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Corteza Prefrontal Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2019 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Corteza Prefrontal Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2019 Tipo del documento: Article