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Radiological characteristics based on isocitrate dehydrogenase mutations and 1p/19q codeletion in grade II and III gliomas.
Yamauchi, Takahiro; Ohno, Makoto; Matsushita, Yuko; Takahashi, Masamichi; Miyakita, Yasuji; Kitagawa, Yosuke; Kondo, Erika; Tsushita, Natsuko; Satomi, Kaishi; Yoshida, Akihiko; Ichimura, Koichi; Narita, Yoshitaka.
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  • Yamauchi T; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Ohno M; Division of Medicine, Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, Japan.
  • Matsushita Y; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. mohno@ncc.go.jp.
  • Takahashi M; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Miyakita Y; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan.
  • Kitagawa Y; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Kondo E; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Tsushita N; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Satomi K; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Yoshida A; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Ichimura K; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan.
  • Narita Y; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan.
Brain Tumor Pathol ; 35(3): 148-158, 2018 Jul.
Article en En | MEDLINE | ID: mdl-29922974
The radiological features of lower-grade gliomas (LGGs) classified according to isocitrate dehydrogenase (IDH) mutations and codeletion of chromosomal arms 1p and 19q (1p/19q codeletion) remain unclear. We aimed to systematically characterize the radiological features of molecularly classified LGGs using IDH and 1p/19q codeletion statuses. One hundred and one LGGs were re-classified into 36 tumors with IDH mutations (IDH-Mut), 35 tumors with IDH-Mut and 1p/19q codeletion (IDH-Mut/Codel), and 30 tumors with wildtype IDH (IDH-Wt). Calcification, heterogeneous signal intensity in T2-weighted images, and cortical invasion were significantly more frequent in IDH-Mut/Codel than in IDH-Mut and IDH-Wt tumors (calcification: 48.6 vs 5.6 and 6.7%, heterogeneity: 94.3 vs 33.3 and 50%, and cortical invasion: 94.3 vs 55.6 and 40.0%, respectively). A frontal location was significantly more frequent for IDH-Mut and IDH-Mut/Codel than for IDH-Wt tumors (52.8 and 71.4 vs 12.1%, respectively), and dense contrast-enhancement was significantly more frequent in IDH-Wt than in IDH-Mut and IDH-Mut/Codel tumors (50.0 vs 2.8 and 2.9%, respectively). In conclusion, IDH-Mut/Codel tumors were characterized by calcification, frontal location, heterogeneous signal intensity, and cortical invasion; IDH-Mut tumors differed from IDH-Wt tumors according to predominant frontal lobe location and less frequent dense enhancement patterns.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 1 / Cromosomas Humanos Par 19 / Encéfalo / Neoplasias Encefálicas / Deleción Cromosómica / Glioma / Mutación Idioma: En Revista: Brain Tumor Pathol Asunto de la revista: CEREBRO / NEOPLASIAS / PATOLOGIA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 1 / Cromosomas Humanos Par 19 / Encéfalo / Neoplasias Encefálicas / Deleción Cromosómica / Glioma / Mutación Idioma: En Revista: Brain Tumor Pathol Asunto de la revista: CEREBRO / NEOPLASIAS / PATOLOGIA Año: 2018 Tipo del documento: Article