Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2&#945; Inhibitor.

Dai, Zhiyu; Zhu, Maggie M; Peng, Yi; Machireddy, Narsa; Evans, Colin E; Machado, Roberto; Zhang, Xianming; Zhao, You-Yang

Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor.

Dai, Zhiyu; Zhu, Maggie M; Peng, Yi; Machireddy, Narsa; Evans, Colin E; Machado, Roberto; Zhang, Xianming; Zhao, You-Yang.

Afiliación

Dai Z; 1 Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Zhu MM; 2 Division of Critical Care, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Peng Y; 3 Department of Pharmacology and.
Machireddy N; 4 Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois.
Evans CE; 1 Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Machado R; 2 Division of Critical Care, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Zhang X; 3 Department of Pharmacology and.
Zhao YY; 4 Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois.

Am J Respir Crit Care Med ; 198(11): 1423-1434, 2018 12 01.

Article en En | MEDLINE | ID: mdl-29924941

Asunto(s)

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/antagonistas & inhibidores; Glucolípidos/administración & dosificación; Insuficiencia Cardíaca/fisiopatología; Hipertensión Pulmonar/fisiopatología; Remodelación Vascular/fisiología; Animales; Western Blotting; Células Cultivadas; Modelos Animales de Enfermedad; Femenino; Técnica del Anticuerpo Fluorescente; Insuficiencia Cardíaca/complicaciones; Humanos; Hipertensión Pulmonar/complicaciones; Masculino; Ratones; Reacción en Cadena de la Polimerasa; Ratas; Ratas Sprague-Dawley; Regulación hacia Arriba/fisiología

Palabras clave

cardiac fibrosis; hypoxia-inducible factor; obliterative vascular remodeling; pharmacological therapy; pulmonary arterial hypertension

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glucolípidos / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Remodelación Vascular / Insuficiencia Cardíaca / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2018 Tipo del documento: Article

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