Synthesis and biological evaluation of some N-(3-(1H-tetrazol-5-yl) phenyl)acetamide derivatives as novel non-carboxylic PTP1B inhibitors designed through bioisosteric modulation.

Maheshwari, Neelesh; Karthikeyan, Chandrabose; Bhadada, Shraddha V; Sahi, Chandan; Verma, Amit K; Hari Narayana Moorthy, N S; Trivedi, Piyush

Maheshwari, Neelesh; Karthikeyan, Chandrabose; Bhadada, Shraddha V; Sahi, Chandan; Verma, Amit K; Hari Narayana Moorthy, N S; Trivedi, Piyush.

Afiliación

Maheshwari N; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, MP 462036, India.
Karthikeyan C; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, MP 462036, India; Department of Pharmacy, Indira Gandhi National Tribal University, Lalpur, Amarkantak, MP 484887, India.
Bhadada SV; Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad 382481, Gujarat, India.
Sahi C; Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh 462066, India.
Verma AK; Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh 462066, India.
Hari Narayana Moorthy NS; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, MP 462036, India; Department of Pharmacy, Indira Gandhi National Tribal University, Lalpur, Amarkantak, MP 484887, India. Electronic address: hari.nmoorthy@gmail.com.
Trivedi P; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, MP 462036, India.

Bioorg Chem ; 80: 145-150, 2018 10.

Article en En | MEDLINE | ID: mdl-29925050

Asunto(s)

Acetamidas/química; Inhibidores Enzimáticos/síntesis química; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Acetamidas/metabolismo; Acetamidas/uso terapéutico; Animales; Sitios de Unión; Glucemia/análisis; Diabetes Mellitus Experimental/inducido químicamente; Diabetes Mellitus Experimental/tratamiento farmacológico; Diseño de Fármacos; Inhibidores Enzimáticos/metabolismo; Inhibidores Enzimáticos/uso terapéutico; Prueba de Tolerancia a la Glucosa; Humanos; Ratones; Ratones Endogámicos C57BL; Simulación del Acoplamiento Molecular; Estructura Terciaria de Proteína; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Ratas; Relación Estructura-Actividad; Tetrazoles/química

Palabras clave

Bioisosterism; Diabetes; N-(3-(1H-tetrazol-5-yl)phenyl)acetamide derivatives; Protein Tyrosine Phosphatase 1B

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Acetamidas Idioma: En Revista: Bioorg Chem Año: 2018 Tipo del documento: Article

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