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The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1.
Pearson, Russell J; Blake, David G; Mezna, Mokdad; Fischer, Peter M; Westwood, Nicholas J; McInnes, Campbell.
Afiliación
  • Pearson RJ; School of Pharmacy, Keele University, Staffordshire ST5 5BG, UK; Department of Chemistry, University of St Andrews, Fife KY16 9ST, UK.
  • Blake DG; Cyclacel Ltd., James Lindsay Place, Dundee DD1 5JJ, UK.
  • Mezna M; Cyclacel Ltd., James Lindsay Place, Dundee DD1 5JJ, UK.
  • Fischer PM; School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, NG7 2RD, UK.
  • Westwood NJ; Department of Chemistry, University of St Andrews, Fife KY16 9ST, UK.
  • McInnes C; Cyclacel Ltd., James Lindsay Place, Dundee DD1 5JJ, UK; Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC 29208, USA. Electronic address: mcinnes@cop.sc.edu.
Cell Chem Biol ; 25(9): 1107-1116.e4, 2018 09 20.
Article en En | MEDLINE | ID: mdl-30017915
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Adenosina Trifosfato / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Proteínas de Ciclo Celular / Inhibidores de Proteínas Quinasas Idioma: En Revista: Cell Chem Biol Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Adenosina Trifosfato / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Proteínas de Ciclo Celular / Inhibidores de Proteínas Quinasas Idioma: En Revista: Cell Chem Biol Año: 2018 Tipo del documento: Article