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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.
Ji, Xuemei; Bossé, Yohan; Landi, Maria Teresa; Gui, Jiang; Xiao, Xiangjun; Qian, David; Joubert, Philippe; Lamontagne, Maxime; Li, Yafang; Gorlov, Ivan; de Biasi, Mariella; Han, Younghun; Gorlova, Olga; Hung, Rayjean J; Wu, Xifeng; McKay, James; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C; Caporaso, Neil; Johansson, Mattias; Liu, Geoffrey; Bojesen, Stig E; Le Marchand, Loic; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C; Bush, William S; Tardon, Adonina; Rennert, Gad; Chen, Chu; Teare, M Dawn; Field, John K; Kiemeney, Lambertus A; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B; Andrew, Angeline S; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A; Pesatori, Angela C; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha.
Afiliación
  • Ji X; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • Bossé Y; Department of Molecular Medicine, Laval University, Québec, G1V 4G5, Canada.
  • Landi MT; Institut universitaire de cardiologie et de pneumologie de Québec, Québec, G1V 4G5, Canada.
  • Gui J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Xiao X; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • Qian D; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • Joubert P; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • Lamontagne M; Institut universitaire de cardiologie et de pneumologie de Québec, Québec, G1V 4G5, Canada.
  • Li Y; Institut universitaire de cardiologie et de pneumologie de Québec, Québec, G1V 4G5, Canada.
  • Gorlov I; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • de Biasi M; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • Han Y; Annenberg School of Communication, University of Pennsylvania, Philadelphia, 19104, PA, USA.
  • Gorlova O; Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, USA.
  • Hung RJ; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • Wu X; Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.
  • McKay J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, M5T 3L9, Canada.
  • Zong X; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
  • Carreras-Torres R; International Agency for Research on Cancer, World Health Organization, Lyon, 69372 CEDEX 08, France.
  • Christiani DC; Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, M5T 3L9, Canada.
  • Caporaso N; International Agency for Research on Cancer, World Health Organization, Lyon, 69372 CEDEX 08, France.
  • Johansson M; Department of Environmental Health, Harvard School of Public Health, Boston, 02115, MA, USA.
  • Liu G; Department of Medicine, Massachusetts General Hospital, Boston, 02115, MA, USA.
  • Bojesen SE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Le Marchand L; International Agency for Research on Cancer, World Health Organization, Lyon, 69372 CEDEX 08, France.
  • Albanes D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, M5T 3L9, Canada.
  • Bickeböller H; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Herlev 2730, Denmark.
  • Aldrich MC; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200 København N, Denmark.
  • Bush WS; Copenhagen General Population Study, Herlev and Gentofte Hospital, Ringvej 75, Copenhagen, Herlev 2730, Denmark.
  • Tardon A; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, HI, USA.
  • Rennert G; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Chen C; Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, 37073, Germany.
  • Teare MD; Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, 37203, TN, USA.
  • Field JK; Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, 37203, TN, USA.
  • Kiemeney LA; Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, 44106, OH, USA.
  • Lazarus P; Faculty of Medicine, University of Oviedo, Oviedo, 33006, Spain.
  • Haugen A; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Campus del Cristo s/n, Oviedo, 33006, Spain.
  • Lam S; Clalit National Cancer Control Center, Carmel Medical Center, Haifa, 34361, Israel.
  • Schabath MB; Faculty of Medicine, Technion, Haifa, 34361, Israel.
  • Andrew AS; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
  • Shen H; School of Health and Related Research, University of Sheffield, Sheffield, S1 4DA, UK.
  • Hong YC; Roy Castle Lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK.
  • Yuan JM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, 6525 EZ, The Netherlands.
  • Bertazzi PA; Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, 99210-1495, WA, USA.
  • Pesatori AC; National Institute of Occupational Health, 0033, Gydas vei 8, 0033, Oslo, Norway.
  • Ye Y; British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, V5Z1L3, Canada.
  • Diao N; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA.
  • Su L; Department of Epidemiology, Geisel School of Medicine, 1 Medical Center Drive, Hanover, 03755, NH, USA.
  • Zhang R; Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, 101 Longmian Ave, Nanjing, 211166, PR China.
  • Brhane Y; Department of Preventive Medicine, Seoul National University College of Medicine, 1 Gwanak-ro, Gwanak-gu, Seoul, 151 742, Republic of Korea.
  • Leighl N; University of Pittsburgh Cancer Institute, Pittsburgh, 15232, PA, USA.
Nat Commun ; 9(1): 3221, 2018 08 13.
Article en En | MEDLINE | ID: mdl-30104567
ABSTRACT
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 15 / Predisposición Genética a la Enfermedad / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 15 / Predisposición Genética a la Enfermedad / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article