Your browser doesn't support javascript.
loading
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; de Wit, Harriet; Davis, Lea K; MacKillop, James; Derringer, Jaime L; Branje, Susan J T; Hartman, Catharina A; Heath, Andrew C; van Lier, Pol A C; Madden, Pamela A F; Mägi, Reedik; Meeus, Wim; Montgomery, Grant W; Oldehinkel, A J; Pausova, Zdenka; Ramos-Quiroga, Josep A; Paus, Tomas; Ribases, Marta; Kaprio, Jaakko; Boks, Marco P M; Bell, Jordana T; Spector, Tim D; Gelernter, Joel; Boomsma, Dorret I; Martin, Nicholas G; MacGregor, Stuart; Perry, John R B; Palmer, Abraham A; Posthuma, Danielle; Munafò, Marcus R; Gillespie, Nathan A; Derks, Eske M; Vink, Jacqueline M.
Afiliación
  • Pasman JA; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
  • Verweij KJH; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
  • Gerring Z; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.
  • Stringer S; Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Sanchez-Roige S; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Treur JL; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
  • Abdellaoui A; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
  • Nivard MG; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.
  • Baselmans BML; Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Ong JS; Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Ip HF; Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • van der Zee MD; Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Bartels M; Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Day FR; Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Fontanillas P; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
  • Elson SL; 23andMe, Inc., Mountain View, CA, USA.
  • Davis LK; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
  • MacKillop J; Vanderbilt Genetics Institute; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
  • Branje SJT; Department of Psychology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
  • Hartman CA; Department of Youth and Family, Utrecht University, Utrecht, the Netherlands.
  • Heath AC; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • van Lier PAC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Madden PAF; Department of Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Mägi R; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Meeus W; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Montgomery GW; Department of Youth and Family, Utrecht University, Utrecht, the Netherlands.
  • Oldehinkel AJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Pausova Z; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Ramos-Quiroga JA; Hospital for Sick Children, Toronto, Ontario, Canada.
  • Paus T; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Ribases M; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Kaprio J; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.
  • Boks MPM; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Bell JT; Rotman Research Institute, Baycrest, Toronto, Ontario, Canada.
  • Spector TD; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Gelernter J; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Boomsma DI; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Martin NG; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.
  • MacGregor S; Institute for Molecular Medicine Finland FIMM, HiLIFE Unit, University of Helsinki, Helsinki, Finland.
  • Perry JRB; Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Palmer AA; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Posthuma D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Munafò MR; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Gillespie NA; Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Derks EM; Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Vink JM; Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nat Neurosci ; 21(9): 1161-1170, 2018 09.
Article en En | MEDLINE | ID: mdl-30150663
ABSTRACT
Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Esquizofrenia / Abuso de Marihuana / Estudio de Asociación del Genoma Completo Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Esquizofrenia / Abuso de Marihuana / Estudio de Asociación del Genoma Completo Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article