The role of α-ketoglutarate-dependent proteins in pluripotency acquisition and maintenance.
J Biol Chem
; 294(14): 5408-5419, 2019 04 05.
Article
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| MEDLINE
| ID: mdl-30181211
ABSTRACT
α-Ketoglutarate is an important metabolic intermediate that acts as a cofactor for several chromatin-modifying enzymes, including histone demethylases and the Tet family of enzymes that are involved in DNA demethylation. In this review, we focus on the function and genomic localization of these α-ketoglutarate-dependent enzymes in the maintenance of pluripotency during cellular reprogramming to induced pluripotent stem cells and in disruption of pluripotency during in vitro differentiation. The enzymatic function of many of these α-ketoglutarate-dependent proteins is required for pluripotency acquisition and maintenance. A better understanding of their specific function will be essential in furthering our knowledge of pluripotency.
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MEDLINE
Asunto principal:
Metilación de ADN
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Reprogramación Celular
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Células Madre Pluripotentes Inducidas
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Histona Demetilasas
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Ácidos Cetoglutáricos
Idioma:
En
Revista:
J Biol Chem
Año:
2019
Tipo del documento:
Article