Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy.

Komarova, Anastasia O; Drenichev, Mikhail S; Dyrkheeva, Nadezhda S; Kulikova, Irina V; Oslovsky, Vladimir E; Zakharova, Olga D; Zakharenko, Alexandra L; Mikhailov, Sergey N; Lavrik, Olga I

Komarova, Anastasia O; Drenichev, Mikhail S; Dyrkheeva, Nadezhda S; Kulikova, Irina V; Oslovsky, Vladimir E; Zakharova, Olga D; Zakharenko, Alexandra L; Mikhailov, Sergey N; Lavrik, Olga I.

Afiliación

Komarova AO; a Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russian Federation.
Drenichev MS; b Department of Natural Sciences , Novosibirsk State University , Novosibirsk , Russian Federation.
Dyrkheeva NS; c Engelhardt Institute of Molecular Biology, Russian Academy of Sciences , Moscow , Russian Federation.
Kulikova IV; a Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russian Federation.
Oslovsky VE; c Engelhardt Institute of Molecular Biology, Russian Academy of Sciences , Moscow , Russian Federation.
Zakharova OD; c Engelhardt Institute of Molecular Biology, Russian Academy of Sciences , Moscow , Russian Federation.
Zakharenko AL; a Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russian Federation.
Mikhailov SN; a Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russian Federation.
Lavrik OI; c Engelhardt Institute of Molecular Biology, Russian Academy of Sciences , Moscow , Russian Federation.

J Enzyme Inhib Med Chem ; 33(1): 1415-1429, 2018 Dec.

Article en En | MEDLINE | ID: mdl-30191738

Asunto(s)

Antineoplásicos/farmacología; Disacáridos/farmacología; Nucleósidos/farmacología; Inhibidores de Fosfodiesterasa/farmacología; Hidrolasas Diéster Fosfóricas/metabolismo; Topotecan/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Proliferación Celular/efectos de los fármacos; Células Cultivadas; Disacáridos/síntesis química; Disacáridos/química; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Estructura Molecular; Nucleósidos/síntesis química; Nucleósidos/química; Inhibidores de Fosfodiesterasa/síntesis química; Inhibidores de Fosfodiesterasa/química; Relación Estructura-Actividad; Topotecan/síntesis química; Topotecan/química

Palabras clave

Disaccharide nucleosides; TDP1 inhibitor; topotecan; tyrosyl-DNA phosphodiesterase 1

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Hidrolasas Diéster Fosfóricas / Topotecan / Disacáridos / Antineoplásicos / Nucleósidos Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article

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