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Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives.
Darwish, Sarah S; Abdel-Halim, Mohammad; Salah, Mohamed; Abadi, Ashraf H; Becker, Walter; Engel, Matthias.
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  • Darwish SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
  • Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
  • Salah M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany.
  • Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
  • Becker W; Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.
  • Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany. Electronic address: ma.engel@mx.uni-saarland.de.
Eur J Med Chem ; 157: 1031-1050, 2018 Sep 05.
Article en En | MEDLINE | ID: mdl-30193214
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tiofenos / Benzamidas / Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Amidas Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tiofenos / Benzamidas / Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Amidas Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article