UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.

Trobiani, L; Favaloro, F L; Di Castro, M A; Di Mattia, M; Cariello, M; Miranda, E; Canterini, S; De Stefano, M E; Comoletti, D; Limatola, C; De Jaco, A

Trobiani, L; Favaloro, F L; Di Castro, M A; Di Mattia, M; Cariello, M; Miranda, E; Canterini, S; De Stefano, M E; Comoletti, D; Limatola, C; De Jaco, A.

Afiliación

Trobiani L; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.
Favaloro FL; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.
Di Castro MA; Department of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.
Di Mattia M; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.
Cariello M; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.
Miranda E; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.; Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Italy.
Canterini S; Department of Psychology, Section of Neuroscience, Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, 00185 Rome, Italy.
De Stefano ME; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.
Comoletti D; Department of Neuroscience and Cell Biology, Department of Pediatrics, Child Health Institute of New Jersey, Rutgers, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Limatola C; Department of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.; Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Italy.; IRCCS Neuromed, Pozzilli (IS), Italy.
De Jaco A; Department Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Center for Research in Neurobiology 'Daniel Bovet', 00185 Rome, Italy.. Electronic address: antonella.dejaco@uniroma1.it.

Neurobiol Dis ; 120: 139-150, 2018 12.

Article en En | MEDLINE | ID: mdl-30201312

Asunto(s)

Trastorno Autístico/metabolismo; Moléculas de Adhesión Celular Neuronal/metabolismo; Cerebelo/metabolismo; Modelos Animales de Enfermedad; Ácido Glutámico/metabolismo; Proteínas de la Membrana/metabolismo; Proteínas del Tejido Nervioso/metabolismo; Respuesta de Proteína Desplegada/fisiología; Animales; Trastorno Autístico/genética; Moléculas de Adhesión Celular Neuronal/genética; Cerebelo/patología; Proteínas de la Membrana/genética; Ratones; Ratones de la Cepa 129; Ratones Transgénicos; Proteínas del Tejido Nervioso/genética; Transmisión Sináptica/fisiología

Palabras clave

Autism spectrum disorders; BiP; Cerebellum; ER stress; KDEL; Miniature excitatory post-synaptic currents; Neuroligin3; R451C knock-in mice; Unfolded protein response; eIF2α

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Moléculas de Adhesión Celular Neuronal / Cerebelo / Ácido Glutámico / Modelos Animales de Enfermedad / Respuesta de Proteína Desplegada / Proteínas de la Membrana / Proteínas del Tejido Nervioso Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article

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