IMB-SD62, a triazolothiadiazoles derivative with promising action against tuberculosis.

Deng, Qi; Meng, Jianzhou; Liu, Yishuang; Guan, Yan; Xiao, Chunling

Deng, Qi; Meng, Jianzhou; Liu, Yishuang; Guan, Yan; Xiao, Chunling.

Afiliación

Deng Q; The National Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: dengqi1992@163.com.
Meng J; The National Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: mengjianzhou@126.com.
Liu Y; The National Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: 77224879@qq.com.
Guan Y; The National Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: guanyan20@163.com.
Xiao C; The National Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: xiaocl318@163.com.

Tuberculosis (Edinb) ; 112: 37-44, 2018 09.

Article en En | MEDLINE | ID: mdl-30205967

Asunto(s)

Antituberculosos/farmacología; Inhibidores Enzimáticos/farmacología; Mycobacterium tuberculosis/efectos de los fármacos; Tiadiazoles/farmacología; Tuberculosis Pulmonar/tratamiento farmacológico; Administración Oral; Oxidorreductasas de Alcohol/antagonistas & inhibidores; Oxidorreductasas de Alcohol/metabolismo; Animales; Antituberculosos/administración & dosificación; Antituberculosos/farmacocinética; Disponibilidad Biológica; Biotransformación; Modelos Animales de Enfermedad; Perros; Inhibidores Enzimáticos/administración & dosificación; Inhibidores Enzimáticos/farmacocinética; Heces/química; Haplorrinos; Humanos; Eliminación Intestinal; Masculino; Ratones Endogámicos BALB C; Microsomas Hepáticos/metabolismo; Mycobacterium tuberculosis/enzimología; Ratas Sprague-Dawley; Tiadiazoles/administración & dosificación; Tiadiazoles/farmacocinética; Distribución Tisular; Tuberculosis Pulmonar/microbiología

Palabras clave

In vivo efficacy; Pharmacokinetics; Shikimate dehydrogenase; Triazolothiadiazoles; Tuberculosis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tiadiazoles / Tuberculosis Pulmonar / Inhibidores Enzimáticos / Mycobacterium tuberculosis / Antituberculosos Idioma: En Revista: Tuberculosis (Edinb) Año: 2018 Tipo del documento: Article

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