Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Rowland, Andrew; Ruanglertboon, Warit; van Dyk, Madelé; Wijayakumara, Dhilushi; Wood, Linda S; Meech, Robyn; Mackenzie, Peter I; Rodrigues, A David; Marshall, Jean-Claude; Sorich, Michael J

Rowland, Andrew; Ruanglertboon, Warit; van Dyk, Madelé; Wijayakumara, Dhilushi; Wood, Linda S; Meech, Robyn; Mackenzie, Peter I; Rodrigues, A David; Marshall, Jean-Claude; Sorich, Michael J.

Afiliación

Rowland A; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Ruanglertboon W; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
van Dyk M; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Wijayakumara D; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Wood LS; Pfizer Worldwide Research and Development, Groton, USA.
Meech R; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Mackenzie PI; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Rodrigues AD; Pfizer Worldwide Research and Development, Groton, USA.
Marshall JC; Pfizer Worldwide Research and Development, Groton, USA.
Sorich MJ; College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Br J Clin Pharmacol ; 85(1): 216-226, 2019 01.

Article en En | MEDLINE | ID: mdl-30340248

Asunto(s)

Variación Biológica Poblacional; Citocromo P-450 CYP3A/metabolismo; Monitoreo de Drogas/métodos; Exosomas/química; Administración Oral; Adulto; Biomarcadores/análisis; Línea Celular; Estudios de Cohortes; Citocromo P-450 CYP3A/análisis; Citocromo P-450 CYP3A/genética; Técnicas de Genotipaje; Glucuronosiltransferasa/análisis; Glucuronosiltransferasa/genética; Voluntarios Sanos; Humanos; Masculino; Espectrometría de Masas; Tasa de Depuración Metabólica; Midazolam/administración & dosificación; Midazolam/farmacocinética; Prueba de Estudio Conceptual; ARN Mensajero/análisis; Adulto Joven

Palabras clave

ADME; biomarkers; cytochrome P450; exosomes

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Monitoreo de Drogas / Citocromo P-450 CYP3A / Exosomas / Variación Biológica Poblacional Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Br J Clin Pharmacol Año: 2019 Tipo del documento: Article

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