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Identification of a novel KLC1-ROS1 fusion in a case of pediatric low-grade localized glioma.
Nakano, Yoshiko; Tomiyama, Arata; Kohno, Takashi; Yoshida, Akihiko; Yamasaki, Kai; Ozawa, Tatsuya; Fukuoka, Kohei; Fukushima, Hiroko; Inoue, Takeshi; Hara, Junichi; Sakamoto, Hiroaki; Ichimura, Koichi.
Afiliación
  • Nakano Y; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. yonakano@ncc.go.jp.
  • Tomiyama A; Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan. yonakano@ncc.go.jp.
  • Kohno T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Yoshida A; Department of Neurosurgery, National Defense Medical College, Saitama, Japan.
  • Yamasaki K; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
  • Ozawa T; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
  • Fukuoka K; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Fukushima H; Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan.
  • Inoue T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Hara J; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Sakamoto H; Department of Pathology, Osaka City General Hospital, Osaka, Japan.
  • Ichimura K; Department of Pathology, Osaka City General Hospital, Osaka, Japan.
Brain Tumor Pathol ; 36(1): 14-19, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30350109
ABSTRACT
The proto-oncogene tyrosine-protein kinase ROS1 (ROS1) is a tyrosine kinase that is closely related to anaplastic lymphoma kinase receptor (ALK). We describe a novel KLC1-ROS1 fusion identified in a case of pediatric low-grade glioma. This was detected by RNA sequencing and confirmed by reverse-transcription PCR and fluorescent in situ hybridization. Immunohistochemical staining for ROS1 was positive in the tumor cytoplasm. In vitro analysis demonstrated the oncogenic activity of this fusion, which was suppressed by the ALK/ROS1 inhibitor, crizotinib. Our case and others suggest that various ROS1 fusions might be present in a subset of pediatric gliomas, which could be targeted for therapy.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Proteínas Tirosina Quinasas / Proteínas Proto-Oncogénicas / Fusión Génica / Glioma / Proteínas Asociadas a Microtúbulos Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Brain Tumor Pathol Asunto de la revista: CEREBRO / NEOPLASIAS / PATOLOGIA Año: 2019 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Proteínas Tirosina Quinasas / Proteínas Proto-Oncogénicas / Fusión Génica / Glioma / Proteínas Asociadas a Microtúbulos Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Brain Tumor Pathol Asunto de la revista: CEREBRO / NEOPLASIAS / PATOLOGIA Año: 2019 Tipo del documento: Article