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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes.
Gonsalves, Stephen G; Dirksen, Robert T; Sangkuhl, Katrin; Pulk, Rebecca; Alvarellos, Maria; Vo, Teresa; Hikino, Keiko; Roden, Dan; Klein, Teri E; Poler, S Mark; Patel, Sephalie; Caudle, Kelly E; Gordon, Ronald; Brandom, Barbara; Biesecker, Leslie G.
Afiliación
  • Gonsalves SG; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Dirksen RT; Department of Pharmacology & Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Sangkuhl K; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Pulk R; Center for Pharmacy Innovation and Outcomes, Geisinger Medical Center, Danville, Pennsylvania, USA.
  • Alvarellos M; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Vo T; Department of Pharmacy Practice, College of Medicine Internal Medicine, College of Pharmacy, University of South Florida, Tampa, Florida, USA.
  • Hikino K; Committee on Clinical Pharmacology and Pharmacogenomics, The University of Chicago, Chicago, Illinois, USA.
  • Roden D; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Klein TE; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Poler SM; Departments of Anesthesiology, Geisinger Medical Center, Danville, Pennsylvania, USA.
  • Patel S; Department of Anesthesiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
  • Caudle KE; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Gordon R; Department of Anesthesiology, University of California San Diego, San Diego, California, USA.
  • Brandom B; Department of Anesthesiology, Mercy Hospital UPMC, North American MH Registry of MHAUS, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Biesecker LG; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Clin Pharmacol Ther ; 105(6): 1338-1344, 2019 06.
Article en En | MEDLINE | ID: mdl-30499100
ABSTRACT
The identification in a patient of 1 of the 50 variants in the RYR1 or CACNA1S genes reviewed here should lead to a presumption of malignant hyperthermia susceptibility (MHS). MHS can lead to life-threatening reactions to potent volatile anesthetic agents or succinylcholine. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of these agents in patients with these RYR1 or CACNA1S variants (updates at https//cpicpgx.org/guidelines and www.pharmgkb.org).
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Farmacogenética / Succinilcolina / Guías de Práctica Clínica como Asunto / Anestésicos por Inhalación / Canal Liberador de Calcio Receptor de Rianodina / Canales de Calcio Tipo L Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies Idioma: En Revista: Clin Pharmacol Ther Año: 2019 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Farmacogenética / Succinilcolina / Guías de Práctica Clínica como Asunto / Anestésicos por Inhalación / Canal Liberador de Calcio Receptor de Rianodina / Canales de Calcio Tipo L Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies Idioma: En Revista: Clin Pharmacol Ther Año: 2019 Tipo del documento: Article