SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker.

Xu, Liyun; Lu, Changchang; Huang, Yanyan; Zhou, Jihang; Wang, Xincheng; Liu, Chaowu; Chen, Jun; Le, Hanbo

Xu, Liyun; Lu, Changchang; Huang, Yanyan; Zhou, Jihang; Wang, Xincheng; Liu, Chaowu; Chen, Jun; Le, Hanbo.

Afiliación

Xu L; Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Lu C; Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Huang Y; Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Zhou J; Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Wang X; Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Liu C; Department of Cardio-Thoracic Surgery, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Chen J; Department of Cardio-Thoracic Surgery, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.
Le H; Department of Cardio-Thoracic Surgery, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China.

BMB Rep ; 51(12): 648-653, 2018 Dec.

Article en En | MEDLINE | ID: mdl-30545439

ABSTRACT

ABSTRACT

Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12. [BMB Reports 2018; 51(12) 648-653].

Asunto(s)

Adenocarcinoma del Pulmón/patología; Biomarcadores de Tumor/metabolismo; Neoplasias Pulmonares/patología; Inhibidor de Tripsina Pancreática de Kazal/metabolismo; Adenocarcinoma del Pulmón/mortalidad; Animales; Proliferación Celular; Femenino; Humanos; Neoplasias Pulmonares/mortalidad; Masculino; Metaloproteinasa 12 de la Matriz/metabolismo; Ratones Endogámicos BALB C; Ratones Desnudos; Persona de Mediana Edad; Invasividad Neoplásica; Modelos de Riesgos Proporcionales; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Estudios Retrospectivos; Tasa de Supervivencia; Inhibidor de Tripsina Pancreática de Kazal/química; Inhibidor de Tripsina Pancreática de Kazal/genética; Regulación hacia Arriba

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Inhibidor de Tripsina Pancreática de Kazal / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: BMB Rep Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2018 Tipo del documento: Article

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