Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.
Proc Natl Acad Sci U S A
; 115(51): 12872-12877, 2018 12 18.
Article
en En
| MEDLINE
| ID: mdl-30559200
ABSTRACT
Antibiotic resistance in bacteria has emerged as a global challenge over the past 90 years, compromising our ability to effectively treat infections. There has been a dramatic increase in antibiotic resistance-associated determinants in bacterial populations, driven by the mobility and infectious nature of such determinants. Bacterial genome flexibility and antibiotic-driven selection are at the root of the problem. Genome evolution and the emergence of highly successful multidrug-resistant clades in different pathogens have made this a global challenge. Here, we describe some of the factors driving the origin, evolution, and spread of the antibiotic resistance genotype.
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1
Base de datos:
MEDLINE
Asunto principal:
Genoma Bacteriano
/
Farmacorresistencia Bacteriana Múltiple
/
Secuenciación Completa del Genoma
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2018
Tipo del documento:
Article