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Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.
Klein, Hans-Ulrich; McCabe, Cristin; Gjoneska, Elizabeta; Sullivan, Sarah E; Kaskow, Belinda J; Tang, Anna; Smith, Robert V; Xu, Jishu; Pfenning, Andreas R; Bernstein, Bradley E; Meissner, Alexander; Schneider, Julie A; Mostafavi, Sara; Tsai, Li-Huei; Young-Pearse, Tracy L; Bennett, David A; De Jager, Philip L.
Afiliación
  • Klein HU; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • McCabe C; Broad Institute, Cambridge, MA, USA.
  • Gjoneska E; Broad Institute, Cambridge, MA, USA.
  • Sullivan SE; Broad Institute, Cambridge, MA, USA.
  • Kaskow BJ; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Tang A; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Smith RV; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Xu J; Broad Institute, Cambridge, MA, USA.
  • Pfenning AR; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Bernstein BE; Broad Institute, Cambridge, MA, USA.
  • Meissner A; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Schneider JA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Mostafavi S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Tsai LH; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Young-Pearse TL; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
  • Bennett DA; Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
  • De Jager PL; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada.
Nat Neurosci ; 22(1): 37-46, 2019 01.
Article en En | MEDLINE | ID: mdl-30559478
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Histonas / Proteínas tau / Epigénesis Genética / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Histonas / Proteínas tau / Epigénesis Genética / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article