A double-hit High-grade B-cell lymphoma with three-way translocation t(3;8;14)(q27;q24;q32) involving BCL6, MYC, and IGH.

De Paoli, Elena; Bandiera, Laura; Ravano, Emanuele; Cesana, Clara; Grillo, Giovanni; Mancini, Valentina; De Canal, Gabriella; Bonoldi, Emanuela; Soriani, Silvia

De Paoli, Elena; Bandiera, Laura; Ravano, Emanuele; Cesana, Clara; Grillo, Giovanni; Mancini, Valentina; De Canal, Gabriella; Bonoldi, Emanuela; Soriani, Silvia.

Afiliación

De Paoli E; Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Bandiera L; Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Ravano E; Division of Hematology ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Cesana C; Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Grillo G; Division of Hematology ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Mancini V; Division of Hematology ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
De Canal G; Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Bonoldi E; Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
Soriani S; Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.

Clin Case Rep ; 6(12): 2411-2415, 2018 Dec.

Article en En | MEDLINE | ID: mdl-30564339

ABSTRACT

ABSTRACT

We describe an High-grade B-cell lymphoma case, in which a complex translocation t(3;8;14) with effects on the genes BCL6, MYC, and IGH, was detected. This case could be the first double-hit lymphoma with a single chromosome rearrangement causing the double effect with three genes involved.

Palabras clave

BCL6; Highgrade Bcell lymphomas; MYC; doublehit lymphoma; t(3;8;14); threeway translocation

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