Aldehyde adducts inhibit 3,4-dihydroxyphenylacetaldehyde-induced &#945;-synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy.

Kumar, Vijaya B; Hsu, Fong-Fu; Lakshmi, Vijaya M; Gillespie, Kathleen N; Burke, William J

Aldehyde adducts inhibit 3,4-dihydroxyphenylacetaldehyde-induced α-synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy.

Kumar, Vijaya B; Hsu, Fong-Fu; Lakshmi, Vijaya M; Gillespie, Kathleen N; Burke, William J.

Afiliación

Kumar VB; Saint Louis Veterans Affairs Medical Center, Saint Louis, MO 63125, USA; Departments of Medicine, School of Medicine, Saint Louis University Medical Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA; Department of Geriatric Research, 3635 Vista at Grand, Saint Louis, MI 63110, USA. Electronic
Hsu FF; Center for Biomedical and Bioorganic Mass Spectrometry, Washington University School of Medicine, 660S. Euclid, Saint Louis, MO 63110, USA.
Lakshmi VM; Saint Louis Veterans Affairs Medical Center, Saint Louis, MO 63125, USA; Departments of Medicine, School of Medicine, Saint Louis University Medical Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA.
Gillespie KN; Department of Health Management & Policy, College for Public Health and Social Justice, Saint Louis University Health Sciences Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA.
Burke WJ; Departments of Neurology, School of Medicine, Saint Louis University Medical Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA; Departments of Medicine, School of Medicine, Saint Louis University Medical Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA.

Eur J Pharmacol ; 845: 65-73, 2019 Feb 15.

Article en En | MEDLINE | ID: mdl-30579934

Asunto(s)

Ácido 3,4-Dihidroxifenilacético/análogos & derivados; Aldehídos/farmacología; Indanos/farmacología; Fármacos Neuroprotectores/farmacología; Enfermedad de Parkinson/tratamiento farmacológico; alfa-Sinucleína/metabolismo; Ácido 3,4-Dihidroxifenilacético/toxicidad; Aldehídos/uso terapéutico; Animales; Indanos/uso terapéutico; Fármacos Neuroprotectores/uso terapéutico; Células PC12; Ratas

Palabras clave

3,4-Dihydroxyphenylacetaldehyde; Schiff base adducts; α-Synuclein aggregation

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Ácido 3,4-Dihidroxifenilacético / Fármacos Neuroprotectores / Aldehídos / Alfa-Sinucleína / Indanos Idioma: En Revista: Eur J Pharmacol Año: 2019 Tipo del documento: Article

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