The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People.
J Neuropathol Exp Neurol
; 78(2): 191-194, 2019 02 01.
Article
en En
| MEDLINE
| ID: mdl-30590671
ABSTRACT
Cerebral small vessel disease in deep penetrating arteries is a major cause of lacunar infarcts, white matter lesions and vascular cognitive impairment. Local cerebral blood flow in these small vessels is controlled by endothelial-derived nitric oxide, which exerts a primary vasodilator stimulus on vascular myocytes, via cytoplasmic cyclic GMP. Here, we investigated whether the cGMP-degrading enzyme phosphodiesterase-5 (PDE5) is present in small penetrating arteries in the deep subcortical white matter of older people. Frontal cortical tissue blocks were examined from donated brains of older people (n = 42, 24 male 18 female, median age 81, range 59-100 years). PDE5, detected by immunohistochemical labeling, was graded as absent, sparse, or abundant in vascular cells within small arteries in subcortical white matter (vessel outer diameter 20-100 µm). PDE5 labeling within arterial myocytes was detected in all cases. Degree of PDE5 expression (absent, sparse, or abundant) was not associated with age or with neuropathological diagnosis of small vessel disease. In conclusion, PDE5 is present in vascular myocytes within small penetrating arteries in older people. This is a potential molecular target for pharmacological interventions.
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Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Arterias Cerebrales
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Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5
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Sustancia Blanca
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Músculo Liso Vascular
Idioma:
En
Revista:
J Neuropathol Exp Neurol
Año:
2019
Tipo del documento:
Article