Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.

Cui, Li-Hua; Li, Cai-Xia; Zhuo, Yu-Zhen; Yang, Lei; Cui, Nai-Qiang; Zhang, Shu-Kun

Cui, Li-Hua; Li, Cai-Xia; Zhuo, Yu-Zhen; Yang, Lei; Cui, Nai-Qiang; Zhang, Shu-Kun.

Afiliación

Cui LH; Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China.
Li CX; Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China.
Zhuo YZ; Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China.
Yang L; Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China.
Cui NQ; Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China.
Zhang SK; Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China. Electronic address: shu1971@163.

Chem Biol Interact ; 300: 18-26, 2019 Feb 25.

Article en En | MEDLINE | ID: mdl-30611790

Asunto(s)

Autofagia/efectos de los fármacos; Ácido Oleanólico/análogos & derivados; Páncreas/efectos de los fármacos; Saponinas/farmacología; Transducción de Señal/efectos de los fármacos; Animales; Células Cultivadas; Matriz Extracelular/metabolismo; Fibrosis; Masculino; Metaloproteinasas de la Matriz/metabolismo; Ácido Oleanólico/farmacología; Ácido Oleanólico/uso terapéutico; Compuestos Orgánicos de Estaño/toxicidad; Páncreas/metabolismo; Páncreas/patología; Células Estrelladas Pancreáticas/citología; Células Estrelladas Pancreáticas/efectos de los fármacos; Células Estrelladas Pancreáticas/metabolismo; Pancreatitis Crónica/inducido químicamente; Pancreatitis Crónica/patología; Pancreatitis Crónica/prevención & control; Pancreatitis Crónica/veterinaria; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas; Ratas Wistar; Saponinas/uso terapéutico; Proteínas Smad/metabolismo; Serina-Treonina Quinasas TOR/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

Autophagy; PI3K/Akt/mTOR; Pancreatic fibrosis; Pancreatic stellate cells; Saikosaponin d; TGFß-1/Smads

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácido Oleanólico / Páncreas / Saponinas / Autofagia / Transducción de Señal Tipo de estudio: Prognostic_studies Idioma: En Revista: Chem Biol Interact Año: 2019 Tipo del documento: Article

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