Dexmedetomidine improves acute stress-induced liver injury in rats by regulating MKP-1, inhibiting NF-&#954;B pathway and cell apoptosis.

Sha, Jichen; Feng, Xiujing; Chen, Yongping; Zhang, Huayun; Li, Bei; Hu, Xueyuan; Fan, Honggang

Dexmedetomidine improves acute stress-induced liver injury in rats by regulating MKP-1, inhibiting NF-κB pathway and cell apoptosis.

Sha, Jichen; Feng, Xiujing; Chen, Yongping; Zhang, Huayun; Li, Bei; Hu, Xueyuan; Fan, Honggang.

Afiliación

Sha J; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Feng X; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Chen Y; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Zhang H; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Li B; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Hu X; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Fan H; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.

J Cell Physiol ; 234(8): 14068-14078, 2019 08.

Article en En | MEDLINE | ID: mdl-30618065

Asunto(s)

Apoptosis/efectos de los fármacos; Fosfatasa 1 de Especificidad Dual/genética; Inflamación/tratamiento farmacológico; Hígado/lesiones; Animales; Conducta Animal; Dexmedetomidina/farmacología; Humanos; Inflamación/genética; Inflamación/patología; Proteínas Quinasas JNK Activadas por Mitógenos/genética; Hígado/efectos de los fármacos; Hígado/patología; Pulmón/efectos de los fármacos; FN-kappa B/genética; Estrés Oxidativo/efectos de los fármacos; Ratas; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Factor de Transcripción ReIA/genética; Proteína Letal Asociada a bcl/genética; Proteínas Quinasas p38 Activadas por Mitógenos/genética

Palabras clave

acute stress; apoptosis; dexmedetomidine; inflammation; liver injury

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Apoptosis / Fosfatasa 1 de Especificidad Dual / Inflamación / Hígado Tipo de estudio: Prognostic_studies Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article

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