Placental Growth Factor and Endothelial Cell-Specific Molecule 1 Levels in Discordant and Concordant Twins and Their Effects on Fetal Growth.
Fetal Pediatr Pathol
; 38(2): 146-152, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30646809
ABSTRACT
OBJECTIVE:
We explored whether fetal twin growth was related to the levels of placental growth factor (PGF) and endothelial cell-specific molecule 1 (ESM-1) and sought correlations between cord blood PGF and ESM1 levels and birth weight discordance.METHODS:
This was a prospective study. We evaluated 79 pairs of twins, thus 158 infants. Twenty-nine (37%) twins were naturally conceived; the remaining 50 (63%) resulted from assisted reproduction.RESULTS:
Nine (11%) sets of twins were monochorionic. Eighteen of the 79 twin sets (22%) were discordant. We found a positive correlation between PGF and ESM-1 levels (r = 0.51, p = 0.001) and between discordance and PGF level (r = 0.430, p = 0.001).CONCLUSION:
The growth discordance may not be attributable to the different PGF levels, but the difference in PGF level may be a consequence.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteoglicanos
/
Peso al Nacer
/
Células Endoteliales
/
Desarrollo Fetal
/
Factor de Crecimiento Placentario
/
Proteínas de Neoplasias
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Fetal Pediatr Pathol
Asunto de la revista:
PATOLOGIA
/
PEDIATRIA
Año:
2019
Tipo del documento:
Article