The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis.
J Leukoc Biol
; 105(3): 519-530, 2019 03.
Article
en En
| MEDLINE
| ID: mdl-30657605
ABSTRACT
The plasminogen system is harnessed in a wide variety of physiological processes, such as fibrinolysis, cell migration, or efferocytosis; and accordingly, it is essential upon inflammation, tissue remodeling, wound healing, and for homeostatic maintenance in general. Previously, we identified a plasminogen receptor in the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R, CD222). Here, we demonstrate by means of genetic knockdown, knockout, and rescue approaches combined with functional studies that M6P/IGF2R is up-regulated on the surface of macrophages, recognizes plasminogen exposed on the surface of apoptotic cells, and mediates plasminogen-induced efferocytosis. The level of uptake of plasminogen-coated apoptotic cells inversely correlates with the TNF-α production by phagocytes indicating tissue clearance without inflammation by this mechanism. Our results reveal an up-to-now undetermined function of M6P/IGF2R in clearance of apoptotic cells, which is crucial for tissue homeostasis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fagocitosis
/
Plasminógeno
/
Receptor IGF Tipo 2
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Leukoc Biol
Año:
2019
Tipo del documento:
Article